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pentobarbital decreases levels of toremifene by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers raise fee of toremifene metabolism, lowering the continuous-condition concentration in serum.Check Intently (1)pentobarbital will lower the extent or effect of tofacitinib by impacting hepatic/intestinal enzyme